NF-kB Activation by Double-Stranded-RNA-Activated Protein Kinase (PKR) Is Mediated through NF-kB-Inducing Kinase and IkB Kinase
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NF-kB-inducing kinase activates IKK-a by phosphorylation of Ser-176
Activation of the transcription factor NF-kB by inf lammatory cytokines involves the successive action of NF-kB-inducing kinase (NIK) and two IkB kinases, IKK-a and IKK-b. Here we show that NIK preferentially phosphorylates IKK-a over IKK-b, leading to the activation of IKK-a kinase activity. This phosphorylation of IKK-a occurs specifically on Ser-176 in the activation loop between kinase subd...
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IKKb/IKBKB (IkB kinase beta), also designated as IKK2, was named after its function of phosphorylating IkB molecules, the inhibitors of NF-kB transcription factors. The kinase activity of IKKb targets two adjacent serine residues of IkB leading to ubiquitination and proteasomal degradation of the inhibitor, followed by release and activation of NF-kB. Many signaling pathways that activate NF-kB...
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